THE AUTHOR

My name is Michael Pyshnov. In 1986, my PhD program in the University of Toronto was terminated and then my ideas, research and discoveries were stolen by my supervisor. (I discovered specific cell arrangements in the embryonic tissue of Drosophila that are responsible for certain mutations. The ideas were based on my previously published papers.) The fraud was covered up by the corrupt university administration and the Canadian government. In 1999, I started publishing the documents of this fraud, see

http://www.universitytorontofraud.com

My area of interest is cell proliferation in the organism. I published my first paper, “Count of Cell Generations”, in 1969 (in Russian):

https://sciencemishandled.files.wordpress.com/2013/03/1969-paper.pdf

The paper considered the possibility that the restriction on the number of cell generations, discovered by L. Hayflick in cell culture, can exist in the organism. I proposed the mechanism of such restriction and proposed the order of cell divisions that keeps the total number of cell generations in the organism close to the Hayflick’s limit. This was a model of the fast proliferating tissue (the crypt of intestinal epithelium) where the tissue can remain in a steady state, maintaining the number of crypt cells present in any given moment constant and preserving its structure unchanged, while new cells are generated. The model appeared in English in 1977 (J.theor.Biol. 68, 247):

http://dx.doi.org/10.1016/0022-5193(77)90163-1

In 1980 (J.theor.Biol. 87, 189), I postulated the existence of the division waves in the tissue and published the 3-dimensional topological model of the crypt in which purely structural considerations resulted in the same order of cell divisions as was postulated in the previous model:

http://dx.doi.org/10.1016/0022-5193(80)90227-1

In this model, the cells are represented as the elements of a hexagonal 2-dimensional crystalline lattice (a tile mosaics). The structure contains dislocations (cells of non-hexagonal shape) that allow the lattice to be curved and folded into the 3-dimensional figure:

Computer program created by S. Fedorov, http://www.cell-division-program.com/ , 2005

Model of crypt

In the tissues of a multicellular organism, the topological information should determine the shape of the structure, the way it develops in morphogenesis from an embryo and the possibilities of replacing the lost parts of the structure in the process of regeneration. In this system, there can only exist certain pathways in the evolution of organisms, leading to a limited number of the possible adult forms and the types of symmetry.

My main discovery was finding the order of cell divisions (both, in time and space) for the model of the tissue proliferating in the adult organism – the intestinal crypt. This appears to be a generic structure for a number of other proliferating tissues.

It later appeared that the topological structure described in 1980 exactly corresponds to the structure of carbon nanotubes. Topologically, the mechanism of growth in these two structures is also identical: see my last publication, “Structure and Growth in the Living Tissue and in Carbon Nanotubes”, M. Pyshnov and S. Fedorov, 2011:

http://arxiv.org/abs/1106.5705

The modeling is very beautiful, but here is the greatest science of all, microscopy:

Spencer microscope with modified illumination

Spencer, ca. 1940, microscope with modified illumination system greatly reducing the halo on the borders of the objects.

Plant interphase nuclei under new system of illumination. Objective 60X

Plant interphase nuclei under new system of illumination. Objective 60X

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